I really hate Nautilus spatial mode, because it is not usable - it opens lots of windows that you need to close afterwards. I don't get Fedora using spatial mode by default. First thing for me to do after installing Fedora is:
gconftool-2 --type boolean --set /apps/nautilus/preferences/always_use_browser true
Do you do the same or leave nautilus set to spatial mode?
UPDATE; I ashamed to admit that but I didn't know about all the shortcuts and I've been using Gnome for years! I'll have to try spatial mode again and report back ;) Thanks for all of your comments.
UPDATE 2: I switched to spatial mode ;)